Current projects as PI:
- Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India Partnership. This R01 project aims at developing peripheral blood makers for the diagnosis of neurocysticercosis in India. It also includes the development of local capacity to run and analyze Electrospray Ionization mass spectrometry (ESI-MS) and to develop monocyte tissue models of cysticercosis infection. This work is a collaboration among the Department of Biostatistics and Epidemiology, the Section of Infectious diseases and the department of Biochemistry and Molecular Biology at the OUHSC, the Department of Neurosciences at Christian Medical College, Vellore, India and Centre for Cellular and Molecular Platforms in Bangalore, India. Funded under the Brain Disorders in the Developing world: Research Across the Lifespan program by the National Institute of Neurological Disorders and Stroke (NINDS) and the Fogarty International Center (FIC) (R01NS098891).
- Hepatitis C in Native Oklahoma: optimizing care and setting a path towards elimination of disease and disparity. The goal of this study is to increase the capacity of the Cherokee Nation Health Services (CNHS) to screen for and provide treatment to HCV positive tribal members in the Cherokee Nation as well as understand risk factors for infection. The ultimate goal is to develop educational and clinical programs to eliminate HCV from the CNHS. I serve as the director of the epidemiology, outcomes and statistics team. This is a collaboration among the Department of Biostatistics and Epidemiology and the Section of Infectious diseases at the OUHSC, CNHS and the Center for Infectious Disease Modeling and Analysis at Yale University. Funded by the Gilead Foundation (MPI: Douglas Drevets, Hélène Carabin, Joge Mera).
Current projects as co-investigator or consultant:
- Oklahoma Shared Clinical and Translational Resources (OSTCR). The overall OSCTR mission is to serve as a catalyst for clinical research which improves health for underserved and underrepresented populations living in rural areas, to improve patient outcomes of these individuals, and to provide these resources to launch new independent IDeA investigator careers. The OSCTR will provide coordination and assistance to investigators in every aspect of clinical and translational research. I serve as the Director of the Novel Methodologies Unit of the Biostatistics, Epidemiology and Research Design Key Component Activity. Funded by the NIH/NIGMS (U54 GM104938, PI: Judith James).
- Microbial Ecologies of Indigenous communities. This study aims at comparing the gut microbiome from extant traditional peoples to those from urban-industrialized populations to assess if a more “sanitized” lifestyle may have adversely changed our relationship with microbiomes. My role is to develop the design for data collection in Burkina Faso. Funded by the National Institute of General Medical Sciences R01GM089886. (PI: Cecil Lewis)
- Cysticercosis Network for Sub-Saharan Africa. This study aims at developing an interdisciplinary research platform integrating basic and epidemiological research, capacity building and international networking. Four African partners - one in Mozambique (M), two in Tanzania (T) and one in Zambia (Z) - and two German partners (both TU Munich) are involved and linked with an international advisory board including OUHSC. My role is to lead the epidemiology taskforce for the network. Funded by the Federal Ministry of Education and Research of Germany. (MPI: Helena Ngowi and Andrea S Winkler).