The Cherokee Nation, Oklahoma State University (OSU), and the Stephenson Cancer Center (SCC) at the University of Oklahoma Health Science Center (OUHSC) have partnered together on a National Cancer Institute-funded Partnerships to Advance Cancer Health Equity (PACHE) P20 program to develop a Cancer Research Education Program (C-REP). The C-REP aims to expand the pool of students, researchers, and collaborators who meaningfully engage in American Indian cancer health equity research. The C-REP includes a series of research experiences, curricula, and outreach programs to provide cancer health equity training and career development to undergraduate students, graduate students, medical students, early stage investigators, as well as SCC and OSU faculty and staff learners.